GM Maize and Roundup Linked to Premature Death and Cancer

SUSTAINABLE PULSE | SEPTEMBER 19, 2012

Countries like Hungary have destroyed all Monsanto GMO corn Fields.

In a study published in “Food and Chemical Toxicology”, researchers led by Professor Gilles-Eric Seralini from CRIIGEN have found that rats fed on a diet containing NK603 Roundup tolerant GM maize or given water containing Roundup, at levels permitted in drinking water and GM crops in the US, developed cancers faster and died earlier than rats fed on a standard diet. They suffered breast cancer and severe liver and kidney damage.

In the first ever study to examine the long-term effects of Monsanto’s Roundup herbicide and the NK603 Roundup-resistant GM maize also developed by Monsanto, the CRIIGEN scientists found that rats exposed to even the smallest amounts, developed mammary tumors and severe liver and kidney damage as early as four months in males, and seven months for females, compared with 23 and 14 months respectively for a control group.

Led by Professor Seralini, the researchers studied 10 groups, each containing 10 male and 10 female rats, over their normal lifetime. Three groups were given Roundup – developed by Monstanto – in their drinking water at three different levels consistent with exposure through the food chain from crops sprayed with the herbicide. Three groups were fed diets containing different proportions of Roundup resistant maize at 11%, 22% and 33%. Three groups were given both Roundup and the GM maize at the same three dosages. The control group was fed an equivalent diet with no Roundup or NK603 containing 33% of non-GM maize.

Dr Michael Antoniou, molecular biologist and gene expert at Kings College, London, and member of CRIIGEN stated: “This is the most thorough research ever published into the health effects of GM food crops and the herbicide Roundup on rats. It shows an extraordinary number of cancers developing earlier and more aggressively – particularly in female animals.  I am shocked by the extreme negative health impacts.”

“The rat has long been used as a surrogate for human toxicity. All new pharmaceutical, agricultural and household substances are, prior to their approval, tested on rats. This is as good an indicator as we can expect that the consumption of GM maize and the herbicide Roundup, impacts seriously on human health,” Antoniou concluded.

The report states: “Similar degrees of pathological symptoms were noticed to occur from the lowest to the highest doses suggesting a threshold effect. This corresponds to levels likely to arise from consumption or environmental exposure, such as either 11% GM maize in food, or 50ng/L of glyphosate in R-formulation [the lowest concentration of Roundup in the rats’ drinking water] as can be found in some contaminated drinking tap water, and which falls within authorized limits.”

  • Up to 50% of males and 70% of females died prematurely (before deaths could be put down to normal aging) compared with only 30% and 20% in the control group.
  • Across all treatments and both sexes, researchers found treated rats developed 2-3 times more large cancers than the control group.
  • By the beginning of the 24th month 50%-80% of females in all treated groups had developed cancers, with up to three tumours per animal. Only 30% of the controls were affected.
  • The first large detectable cancers appeared after four and seven months in males and females respectively but only after 14 months in the control group. However, the majority of cancers were only detectable after 18 months.

The research findings raise serious questions about the current regulatory process for licensing industrial chemicals, pesticides and other novel crops. The scientists observe that all GM crops have been approved safe for consumption on the basis of 90-day animal feeding trials. They also point out that only Roundup’s active principle, glyphosate, has been tested rather than the commercial product, which includes ingredients that enable the glyphosate to penetrate plants more efficiently.

For Full Information on this study click here: www.criigen.org

Full Download of Study Paper: sustainablefoodtrust.org

Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize

Abstract

The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated with or without Roundup, and Roundup alone (from 0.1 ppb in water), were studied 2 years in rats. In females, all treated groups died 2–3 times more than controls, and more rapidly. This difference was visible in 3 male groups fed GMOs. All results were hormone and sex dependent, and the pathological pro-files were comparable. Females developed large mammary tumors almost always more often than and before controls, the pituitary was the second most disabled organ; the sex hormonal balance was modified by GMO and Roundup treatments. In treated males, liver congestions and necrosis were 2.5–5.5 times higher. This pathology was confirmed by optic and transmission electron microscopy. Marked and severe kidney nephropathies were also generally 1.3–2.3 greater. Males presented 4 times more large palpable tumors than controls which occurred up to 600 days earlier. Biochemistry data confirmed very significant kidney chronic deficiencies; for all treatments and both sexes, 76% of the altered parameters were kidney related. These results can be explained by the non linear endocrine-disrupting effects of Roundup, but also by the over expression of the transgene in the GMO and its metabolic consequences.

Authors

Gilles-Eric Séralini, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, Joël Spiroux de Vendômois

Plaguicidas agrícolas perturban Hormonas Masculinas

Scientific American
Adaptación Luis R. Miranda
Febrero 17, 2011

Muchos pesticidas agrícolas – entre ellos algunos ya probados y que se encuentran comúnmente en los alimentos – alteran las hormonas masculinas; esto según nuevas pruebas realizadas por científicos británicos.

En el estudio, los científicos recomiendan que todos los plaguicidas en uso hoy sean evaluados para comprobar si estos bloquean testosterona y otros andrógenos, las hormonas críticas para el sistema de salud reproductiva para hombres y niños.

“Nuestros resultados indican que deben ser efectuadas pruebas sistemáticas para constatar cuanto la actividad androgénica está siendo afectada por los plaguicidas utilizados en la actualidad, y estas pruebas se necesitan con urgencia”, escribieron los científicos de la Universidad de Londres, el Centro de Toxicología, dirigido por el Profesor Andreas Kortenkamp.

Treinta de los 37 pesticidas ampliamente utilizados en el estudio bloquearon o imitaron hormonas masculinas. Dieciséis de los 30 no parecían tener ninguna influencia en actividad hormonal hasta ahora, mientras que hubo algunas pruebas anteriores para los otros 14, según el estudio, publicado en Internet el pasado jueves en la revista científica Environmental Health Perspectives.

La mayoría de los disruptores hormonales recientemente descubiertos son fungicidas aplicados a los cultivos de frutas y hortalizas, incluidas las fresas y lechuga. Las huellas de los productos químicos permanecen en los alimentos.

“Este estudio indica que, como es lógico, hay muchos disruptores endocrinos otros que aún no hemos identificado o de los cuales sabemos muy poco,” dijo Emily de Barrett, un profesor de la Universidad de Rochester, asistente de obstetricia y ginecología, que no participó en el estudio.

“Esto pone de relieve el problema evidente que muchos de los productos químicos que son más utilizados hoy en día, incluyendo los pesticidas, simplemente no están debidamente evaluados y pueden tener graves impactos a largo plazo en la salud y el desarrollo”, dijo Barrett, que estudia cómo los productos químicos ambientales afectan los sistemas reproductivos humanos.

Los hallazgos llegan en el momento en que la Agencia de Protección Ambiental de Estados Unidos enfrenta oposición de la industria de los plaguicidas después de ampliar su Programa de Detección de disruptores endocrinos, que requiere la evaluación de cerca de 200 sustancias químicas que se encuentran en alimentos y agua potable para ver si interfieren con el estrógeno, los andrógenos u hormonas tiroideas.

Ninguno de los 16 plaguicidas que según el estudio afectan la actividad hormonal están incluidos en el programa de la EPA, lo que significa que no están actualmente seleccionados para revisión y no hay planes para hacerlo.

El programa de la EPA ha tardado en ponerse en práctica, en gran parte debido a una controversia sobre los métodos de ensayo. Los grupos ecologistas critican a la EPA, que fue creada por autoridad del Congreso en 1996, para agilizar la evaluación de substancias. Desde entonces solo un pequeño grupo de productos químicos es evaluado del total de substancias usadas en productos como pesticidas, fungicidas y plaguicidas. Sin embargo, funcionarios de la industria química dicen que las pruebas cuestan hasta 1 millón de dólares por químico y las técnicas no han sido validadas en su totalidad. También destacan que los resultados positivos no significa necesariamente que los plaguicidas que estén perjudicando la salud humana.

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Agricultural pesticides disrupt male hormones

Scientific American

Many agricultural pesticides – including some previously untested and commonly found in food  – disrupt male hormones, according to new tests conducted by British scientists.

The scientists strongly recommended that all pesticides in use today be screened to check if they block testosterone and other androgens, the hormones critical to a healthy reproductive system for men and boys.

“Our results indicate that systematic testing for anti-androgenic activity of currently used pesticides is urgently required,” wrote the scientists from University of London’s Centre for Toxicology, led by Professor Andreas Kortenkamp.

Thirty out of 37 widely used pesticides tested by the group blocked or mimicked male hormones. Sixteen of the 30 had no known hormonal activity until now, while there was some previous evidence for the other 14, according to the study, published online last Thursday in the scientific journal Environmental Health Perspectives.

Most of the newly discovered hormone disruptors are fungicides applied to fruit and vegetable crops, including strawberries and lettuce. Traces of the chemicals remain in foods.

“This study indicates that, not surprisingly, there are many other endocrine disruptors that we have not yet identified or know very little about,” said Emily Barrett, a University of Rochester assistant professor in obstetrics and gynecology who was not involved in the study.

“This underlines the glaring problem that many of the chemicals that are most widely used today, including pesticides, are simply not adequately tested and may have serious long-term impacts on health and development,” said Barrett, who studies how environmental chemicals affect human reproduction.

The findings come as the U.S. Environmental Protection Agency faces opposition from the pesticide industry after expanding its Endocrine Disruptor Screening Program, which requires testing of about 200 chemicals found in food and drinking water to see if they interfere with estrogen, androgens or thyroid hormones.

None of the 16 pesticides with the newly discovered hormonal activity is included in the EPA’s program, which means they are not currently screened and there are no plans to do so.

The EPA’s program has been slow to implement, largely due to a controversy over testing methods. Environmental groups criticize the EPA, which was granted the authority by Congress in 1996, for taking so long to order manufacturers to test only a small group of chemicals. But chemical industry officials say that the tests cost up to $1 million per chemical and the techniques have not been fully validated. They also stress that positive results don’t necessarily mean that the pesticides are harming human reproduction.

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